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Literature summary for 4.2.99.18 extracted from
- Cellular localization of the apurinic/apyrimidinic endodeoxyribonucleases in rat liver (1980), Eur. J. Biochem., 107, 555-563.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| Triton X-100 | increases activity of nuclear membrane enzyme, activity of nuclear sap and chromatin non-histone enzyme untouched or decreased | Rattus norvegicus |  |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| Triton X-100 | increases activity of nuclear membrane enzyme, activity of nuclear sap and chromatin non-histone enzyme untouched or decreased | Rattus norvegicus | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytoplasm | - |
Rattus norvegicus | 5737 | - |
| membrane | - |
Rattus norvegicus | 16020 | - |
| mitochondrion | - |
Rattus norvegicus | 5739 | - |
| additional information | different cell compartments contain different enzyme species | Rattus norvegicus | - |
- |
| nucleus | also in nuclear sap and nuclear membranes | Rattus norvegicus | 5634 | - |
| nucleus | mostly in chromatin non-histones | Rattus norvegicus | 5634 | - |
| soluble | - |
Rattus norvegicus | - |
- |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| additional information | - |
nuclear sap enzyme has higher molecular weight than chromatin enzyme | Rattus norvegicus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| DNA | Rattus norvegicus | - |
fragments of DNA | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| DNA | - |
Rattus norvegicus | fragments of DNA | - |
? | |
Temperature Stability [°C]
| Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 45 | - |
half-life: cytoplasmic enzyme and nuclear membrane enzyme: 25 min, non-histone enzyme: 2.5 min, nuclear sap enzyme: stable | Rattus norvegicus |
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Release 2023.1 (January 2023)
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