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Literature summary for 4.2.99.18 extracted from

  • Kim, J.; Linn, S.
    The mechanism of action of E. coli endonuclease III and T4 UV endonuclease (endonuclease V) at AP sites (1988), Nucleic Acids Res., 16, 1135-1141.
    View publication on PubMedView publication on EuropePMC

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
DNA Escherichia coli
-
fragments of DNA
-
?
DNA Tequatrovirus T4
-
fragments of DNA
-
?

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
endonuclease III
-
Tequatrovirus T4
-
-
-

Reaction

Reaction Comment Organism Reaction ID
the C-O-P bond 3' to the apurinic or apyrimidinic site in DNA is broken by a beta-elimination reaction, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate mechanism Escherichia coli
the C-O-P bond 3' to the apurinic or apyrimidinic site in DNA is broken by a beta-elimination reaction, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate mechanism Tequatrovirus T4

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
DNA
-
Escherichia coli fragments of DNA
-
?
DNA
-
Tequatrovirus T4 fragments of DNA
-
?
DNA catalyzes phosphodiester bond cleavage via a lyase- rather than a hydrolase mechanism Escherichia coli fragments of DNA
-
?
DNA catalyzes phosphodiester bond cleavage via a lyase- rather than a hydrolase mechanism Tequatrovirus T4 fragments of DNA
-
?