Literature summary for 4.2.3.B28 extracted from

Nakano, C.; Hoshino, T.; Sato, T.; Toyomasu, T.; Dairi, T.; Sassa, T.
Substrate specificity of the CYC2 enzyme from Kitasatospora griseola: production of sclarene, biformene and novel bicyclic diterpenes by the enzymatic reactions of labdane- and halimane-type diterpene diphosphates (2010), Tetrahedron Lett., 51, 125-128.

No PubMed abstract available

Search for more literature for 4.2.3.B28

Metals/Ions

Metals/Ions	Comment	Organism	Structure
Mg2+	presence is essential for enzymic activity	Kitasatospora griseola

Organism

Organism	UniProt	Comment	Textmining
Kitasatospora griseola	Q9AJE3	-	-

Reaction

Reaction	Comment	Organism	Reaction ID
tuberculosinyl diphosphate = (4aS,5R,6S)-1,1,5,6-tetramethyl-5-(3-methylidenepent-4-en-1-yl)-1,2,3,4,4a,5,6,7-octahydronaphthalene + diphosphate	compound has not been found in nature	Kitasatospora griseola	a

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
tuberculosinyl diphosphate	-	Kitasatospora griseola	(4aS,5R,6S)-1,1,5,6-tetramethyl-5-(3-methylidenepent-4-en-1-yl)-1,2,3,4,4a,5,6,7-octahydronaphthalene + diphosphate	yield about 50%. Compound has not been found in nature	?

Synonyms

Synonyms	Comment	Organism
Cyc2	ambiguous	Kitasatospora griseola
diterpene cyclase-2	ambiguous	Kitasatospora griseola

Temperature Optimum [°C]

Temperature Optimum [°C]	Temperature Optimum Maximum [°C]	Comment	Organism
30	-	assay at	Kitasatospora griseola
50	-	-	Kitasatospora griseola

pH Optimum

pH Optimum Minimum	pH Optimum Maximum	Comment	Organism
6.8	-	-	Kitasatospora griseola
7.5	-	assay at	Kitasatospora griseola

pH Range

pH Minimum	pH Maximum	Comment	Organism
6.8	7.5	-	Kitasatospora griseola

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Release 2023.1 (January 2023)