BRENDA - Enzyme Database
show all sequences of 4.2.3.9

Aristolochene synthase: purification, molecular cloning, high-level expression in Escherichia coli, and characterization of the Aspergillus terreus cyclase

Cane, D.E.; Kang, I.; Arch. Biochem. Biophys. 376, 354-364 (2000)

Data extracted from this reference:

Cloned(Commentary)
Commentary
Organism
high-level expression in Escherichia coli
Aspergillus terreus
Inhibitors
Inhibitors
Commentary
Organism
Structure
Cu2+
-
Aspergillus terreus
Mn2+
above 1.0 mM
Aspergillus terreus
Mn2+
-
Penicillium roqueforti
KM Value [mM]
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
0.0000135
-
trans,trans-farnesyl diphosphate
pH 8.0, 30C, native enzyme
Aspergillus terreus
0.0000148
-
trans,trans-farnesyl diphosphate
pH 8.0, 30C, recombinant enzyme
Aspergillus terreus
0.00052
-
trans,trans-farnesyl diphosphate
pH 8.0, 30C, recombinant enzyme
Penicillium roqueforti
Metals/Ions
Metals/Ions
Commentary
Organism
Structure
Co2+
can substitute for Mg2+ over the concentration range of 0.16 -5.0 mM
Aspergillus terreus
Mg2+
divalent cation required, 5 mM Mg2+ preferred
Aspergillus terreus
Mg2+
-
Penicillium roqueforti
Mn2+
Mn2+ can replace Mg2+ at 0.1-0.2 mM
Aspergillus terreus
Mn2+
-
Penicillium roqueforti
Molecular Weight [Da]
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
36480
-
x * 36480, calculation from nucleotide sequence
Aspergillus terreus
39000
-
x * 39000, SDS-PAGE
Aspergillus terreus
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Aspergillus terreus
-
-
-
Penicillium roqueforti
-
-
-
Purification (Commentary)
Commentary
Organism
native and recombinant enzyme
Aspergillus terreus
Specific Activity [micromol/min/mg]
Specific Activity Minimum [mol/min/mg]
Specific Activity Maximum [mol/min/mg]
Commentary
Organism
0.0236
-
native enzyme
Aspergillus terreus
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
trans,trans-farnesyl diphosphate
-
644244
Aspergillus terreus
aristolochene + diphosphate
-
644244
Aspergillus terreus
?
trans,trans-farnesyl diphosphate
-
644244
Penicillium roqueforti
aristolochene + diphosphate
-
644244
Penicillium roqueforti
?
Subunits
Subunits
Commentary
Organism
?
x * 36480, calculation from nucleotide sequence; x * 39000, SDS-PAGE
Aspergillus terreus
?
-
Penicillium roqueforti
Turnover Number [1/s]
Turnover Number Minimum [1/s]
Turnover Number Maximum [1/s]
Substrate
Commentary
Organism
Structure
0.014
-
trans,trans-farnesyl diphosphate
pH 8.0, 30C, native enzyme
Aspergillus terreus
0.015
-
trans,trans-farnesyl diphosphate
pH 8.0, 30C, recombinant enzyme
Aspergillus terreus
0.043
-
trans,trans-farnesyl diphosphate
pH 8.0, 30C, recombinant enzyme
Penicillium roqueforti
pH Optimum
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
8
-
recombinant enzyme, HEPES buffer
Aspergillus terreus
Cloned(Commentary) (protein specific)
Commentary
Organism
high-level expression in Escherichia coli
Aspergillus terreus
Inhibitors (protein specific)
Inhibitors
Commentary
Organism
Structure
Cu2+
-
Aspergillus terreus
Mn2+
above 1.0 mM
Aspergillus terreus
Mn2+
-
Penicillium roqueforti
KM Value [mM] (protein specific)
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
0.0000135
-
trans,trans-farnesyl diphosphate
pH 8.0, 30C, native enzyme
Aspergillus terreus
0.0000148
-
trans,trans-farnesyl diphosphate
pH 8.0, 30C, recombinant enzyme
Aspergillus terreus
0.00052
-
trans,trans-farnesyl diphosphate
pH 8.0, 30C, recombinant enzyme
Penicillium roqueforti
Metals/Ions (protein specific)
Metals/Ions
Commentary
Organism
Structure
Co2+
can substitute for Mg2+ over the concentration range of 0.16 -5.0 mM
Aspergillus terreus
Mg2+
divalent cation required, 5 mM Mg2+ preferred
Aspergillus terreus
Mg2+
-
Penicillium roqueforti
Mn2+
Mn2+ can replace Mg2+ at 0.1-0.2 mM
Aspergillus terreus
Mn2+
-
Penicillium roqueforti
Molecular Weight [Da] (protein specific)
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
36480
-
x * 36480, calculation from nucleotide sequence
Aspergillus terreus
39000
-
x * 39000, SDS-PAGE
Aspergillus terreus
Purification (Commentary) (protein specific)
Commentary
Organism
native and recombinant enzyme
Aspergillus terreus
Specific Activity [micromol/min/mg] (protein specific)
Specific Activity Minimum [mol/min/mg]
Specific Activity Maximum [mol/min/mg]
Commentary
Organism
0.0236
-
native enzyme
Aspergillus terreus
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
trans,trans-farnesyl diphosphate
-
644244
Aspergillus terreus
aristolochene + diphosphate
-
644244
Aspergillus terreus
?
trans,trans-farnesyl diphosphate
-
644244
Penicillium roqueforti
aristolochene + diphosphate
-
644244
Penicillium roqueforti
?
Subunits (protein specific)
Subunits
Commentary
Organism
?
x * 36480, calculation from nucleotide sequence; x * 39000, SDS-PAGE
Aspergillus terreus
?
-
Penicillium roqueforti
Turnover Number [1/s] (protein specific)
Turnover Number Minimum [1/s]
Turnover Number Maximum [1/s]
Substrate
Commentary
Organism
Structure
0.014
-
trans,trans-farnesyl diphosphate
pH 8.0, 30C, native enzyme
Aspergillus terreus
0.015
-
trans,trans-farnesyl diphosphate
pH 8.0, 30C, recombinant enzyme
Aspergillus terreus
0.043
-
trans,trans-farnesyl diphosphate
pH 8.0, 30C, recombinant enzyme
Penicillium roqueforti
pH Optimum (protein specific)
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
8
-
recombinant enzyme, HEPES buffer
Aspergillus terreus
Other publictions for EC 4.2.3.9
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [C]
Temperature Range [C]
Temperature Stability [C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [C] (protein specific)
Temperature Range [C] (protein specific)
Temperature Stability [C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
747103
Chen
Probing the role of active si ...
Aspergillus terreus
Biochemistry
55
2864-2874
2016
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1
9
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7
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1
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1
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1
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8
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2
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8
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7
7
747509
Faraldos
Enzymatic synthesis of natura ...
Penicillium roqueforti
Chem. Commun. (Camb.)
52
14027-14030
2016
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1
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746589
Rising
Formation of a novel macrocyc ...
Nicotiana tabacum
ACS Chem. Biol.
10
1729-1736
2015
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1
1
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1
2
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1
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729236
Chen
Mechanistic insights from the ...
Aspergillus terreus
Biochemistry
52
5441-5453
2013
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1
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729242
van der Kamp
Conformational change and liga ...
Aspergillus terreus
Biochemistry
52
8094-8105
2013
-
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1
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1
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729580
Faraldos
The role of aristolochene synt ...
Penicillium roqueforti
Chem. Commun. (Camb. )
48
3230-3232
2012
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9
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7
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7
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9
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7
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1
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7
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7
7
715288
Faraldos
Probing eudesmane cation-pi in ...
Penicillium roqueforti
J. Am. Chem. Soc.
133
13906-13909
2011
-
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1
-
5
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-
5
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2
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1
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5
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1
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5
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5
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1
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5
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5
5
716415
Faraldos
Templating effects in aristolo ...
Penicillium roqueforti
Org. Biomol. Chem.
9
6920-6923
2011
-
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-
8
-
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9
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2
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1
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9
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8
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9
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1
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9
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9
9
716419
Faraldos
Inhibition of (+)-aristolochen ...
Penicillium roqueforti
Org. Lett.
13
1202-1205
2011
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2
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1
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704204
Faraldos
Bisabolyl-derived sesquiterpen ...
Nicotiana tabacum
J. Am. Chem. Soc.
132
4281-4289
2010
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1
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1
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2
2
705304
Faraldos
Intermediacy of eudesmane cati ...
Penicillium roqueforti
J. Org. Chem.
75
1119-1125
2010
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1
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2
1
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1
1
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2
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1
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1
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1
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1
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1
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1
1
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1
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1
1
706047
Miller
6- and 14-Fluoro farnesyl diph ...
Penicillium roqueforti
Org. Biomol. Chem.
7
962-975
2009
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1
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691962
Christianson
Unearthing the roots of the te ...
Aspergillus terreus
Curr. Opin. Chem. Biol.
12
141-150
2008
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693062
Shishova
X-ray crystallographic studies ...
Aspergillus terreus
J. Biol. Chem.
283
15431-15439
2008
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1
1
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1
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1
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1
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694515
Miller
Stereochemistry of eudesmane c ...
Penicillium roqueforti
Org. Biomol. Chem.
6
2346-2354
2008
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1
-
1
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1
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1
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2
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2
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1
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1
1
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678256
Shishova
X-ray crystal structure of ari ...
Aspergillus terreus
Biochemistry
46
1941-1951
2007
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1
1
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1
1
1
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3
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1
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679187
Yu
Probing the reaction mechanism ...
Escherichia coli
Chem. Commun. (Camb. )
2007
4155-4157
2007
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1
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1
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679218
Miller
Aristolochene synthase-catalyz ...
Penicillium roqueforti
ChemBioChem
8
1819-1825
2007
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1
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680359
Allemann
Synthetic efficiency in enzyme ...
Penicillium roqueforti
J. Am. Chem. Soc.
129
13008-13013
2007
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1
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1
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3
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1
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1
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1
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1
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682223
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Stabilisation of transition st ...
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1
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2
1
1
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16
1
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1
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7
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8
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1
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1
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1
1
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2
1
1
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16
1
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664584
Forcat
Dual role for phenylalanine 17 ...
Penicillium roqueforti
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2094-2095
2004
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2
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2
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1
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1
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2
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665301
Felicetti
Aristolochene synthase: mechan ...
Aspergillus terreus, Penicillium roqueforti
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7212-7221
2004
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16
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14
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4
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2
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12
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16
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14
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2
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12
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644243
Deligeorgopoulou
Evidence for differential fold ...
Penicillium roqueforti
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2003
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1
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4
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5
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3
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1
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2
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5
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1
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6
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5
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1
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2
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5
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3
3
644241
Calvert
-
Tyrosine 92 of aristolochene s ...
Penicillium roqueforti
Chem. Commun. (Camb.)
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2002
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1
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1
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1
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1
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644242
Calvert
Germacrene A is a product of t ...
Penicillium roqueforti
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11636-11641
2002
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1
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1
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1
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1
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644240
Caruthers
Crystal structure determinatio ...
Penicillium roqueforti
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1
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1
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1
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644244
Cane
Aristolochene synthase: purifi ...
Aspergillus terreus, Penicillium roqueforti
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376
354-364
2000
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1
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2
2
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3
1
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1
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3
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3
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2
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1
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1
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2
2
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3
1
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644239
Proctor
Aristolochene synthase. Isolat ...
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1
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1
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1
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1
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2
1
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644236
Cane
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Aristolochene biosynthesis. St ...
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644237
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Aristolochene biosynthesis and ...
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Hohn
Purification and characterizat ...
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1
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