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Literature summary for 4.2.3.75 extracted from

  • He, X.; Cane, D.E.
    Mechanism and stereochemistry of the germacradienol/germacrene D synthase of Streptomyces coelicolor A3(2) (2004), J. Am. Chem. Soc., 126, 2678-2679.
    View publication on PubMed

Organism

Organism UniProt Comment Textmining
Streptomyces coelicolor
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bifunctional germacradienol/germacrene D synthase
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Streptomyces coelicolor A3(2)
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bifunctional germacradienol/germacrene D synthase
-

Reaction

Reaction Comment Organism Reaction ID
(2E,6E)-farnesyl diphosphate = (-)-germacrene D + diphosphate formation of (-)-germacrene D involves a stereospecific 1,3-hydride shift of H-1si of farnesyl diphosphate Streptomyces coelicolor

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(2E,6E)-farnesyl diphosphate
-
Streptomyces coelicolor (-)-germacrene D + diphosphate main product is germacradienol, about 15% formation of (-)-(7S)-germacrene ?
(2E,6E)-farnesyl diphosphate
-
Streptomyces coelicolor A3(2) (-)-germacrene D + diphosphate main product is germacradienol, about 15% formation of (-)-(7S)-germacrene ?