Literature summary for 4.2.3.68 extracted from

Yu, F.; Harada, H.; Yamasaki, K.; Okamoto, S.; Hirase, S.; Tanaka, Y.; Misawa, N.; Utsumi, R.
Isolation and functional characterization of a beta-eudesmol synthase, a new sesquiterpene synthase from Zingiber zerumbet Smith (2008), FEBS Lett., 582, 565-572.

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Application

Application	Comment	Organism
synthesis	introduction of a gene cluster encoding six enzymes of the mevalonate pathway into Escherichia coli and coexpression with ZSS2. When supplemented with mevalonate, the engineered Escherichia coli produces a similar sesquiterpene profile to that produced in the in vitro enzyme assay, and the yield of beta-eudesmol reaches 100 mg/l	Zingiber zerumbet

Cloned(Commentary)

Cloned (Comment)	Organism
expression in Escherichia coli	Zingiber zerumbet

Organism

Organism	UniProt	Comment	Textmining
Zingiber zerumbet	B1B1U4	-	-
Zingiber zerumbet Smith	B1B1U4	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
additional information	no expression in leaf	Zingiber zerumbet	-
rhizome	strong seasonal variations in accumulation of transcript, strongest expression in summer	Zingiber zerumbet	-
stem	less abundant than in rhizome	Zingiber zerumbet	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
(2E,6E)-farnesyl diphosphate + H2O	-	Zingiber zerumbet	beta-eudesmol + diphosphate	beta-eudesmol accounts for 72.4% of the total products, followed by 10-epi-gamma-eudesmol at 11.2%, alpha-eudesmol at 7.1% and aristolene at 6.1%	?
(2E,6E)-farnesyl diphosphate + H2O	-	Zingiber zerumbet Smith	beta-eudesmol + diphosphate	beta-eudesmol accounts for 72.4% of the total products, followed by 10-epi-gamma-eudesmol at 11.2%, alpha-eudesmol at 7.1% and aristolene at 6.1%	?

Synonyms

Synonyms	Comment	Organism
ZSS2	-	Zingiber zerumbet

Expression

Organism	Comment	Expression
Zingiber zerumbet	strong seasonal variations in accumulation of transcript, strongest expression in summer	additional information

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Release 2023.1 (January 2023)