Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(6R)-6-fluoro-5-enoylpyruvylshikimate 3-phosphate | IC50 is 0.0005 mM when the enzyme is preincubated with the inhibitor, the IC50 is 0.25 mM when the enzyme is not preincubated with the inhibitor, inhibition is not absolutely irreversible | Escherichia coli |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Escherichia coli | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
O5-(1-carboxyvinyl)-3-phosphoshikimate | evidence for a radical mechanism | Escherichia coli | chorismate + phosphate | - |
? |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
FMN | cofactor | Escherichia coli | |
additional information | no activity with 5-deaza-FMN | Escherichia coli |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.25 | - |
IC50 is 0.0005 mM when the enzyme is preincubated with the inhibitor, the IC50 is 0.25 mM when the enzyme is not preincubated with the inhibitor, inhibition is not absolutely irreversible | Escherichia coli | (6R)-6-fluoro-5-enoylpyruvylshikimate 3-phosphate |