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Literature summary for 4.2.3.37 extracted from
- Characterization of a silent sesquiterpenoid biosynthetic pathway in Streptomyces avermitilis controlling epi-isozizaene albaflavenone biosynthesis and isolation of a new oxidized epi-isozizaene metabolite (2011), Microb. Biotechnol., 4, 184-191.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expression in Escherichia coli | Streptomyces avermitilis |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.000125 | - |
(2E,6E)-farnesyl diphosphate | pH 7.0, 30°C | Streptomyces avermitilis |  |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | required | Streptomyces avermitilis | |
| Mn2+ | 32% of the activity with Mg2+ | Streptomyces avermitilis | |
| Zn2+ | 5% of the activity with Mg2+ | Streptomyces avermitilis | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Streptomyces avermitilis | Q82IV1 | - |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| (2E,6E)-farnesyl diphosphate | - |
Streptomyces avermitilis | (+)-epi-isozizaene + diphosphate | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| SAV_3032 | - |
Streptomyces avermitilis |
| TPS2 | - |
Streptomyces avermitilis |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 30 | - |
assay at | Streptomyces avermitilis |
Turnover Number [1/s]
| Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.00026 | - |
(2E,6E)-farnesyl diphosphate | pH 7.0, 30°C | Streptomyces avermitilis | |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7 | - |
- |
Streptomyces avermitilis |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | Streptomyces avermitilis does not produce epi-isozizaene or any of its oxidized derivatives, albaflavenols and albaflavenone, in any culture conditions examined. Recombinant SAV_3032 protein expressed in Escherichia coli catalyses the Mg2+-dependent cyclization of farnesyl diphosphate to epi-isozizaene | Streptomyces avermitilis |
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Release 2023.1 (January 2023)
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