Literature summary for 4.2.3.37 extracted from

Lin, X.; Cane, D.E.
Biosynthesis of the sesquiterpene antibiotic albaflavenone in Streptomyces coelicolor. Mechanism and stereochemistry of the enzymatic formation of epi-isozizaene (2009), J. Am. Chem. Soc., 131, 6332-6333.

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Cloned(Commentary)

Cloned (Comment)	Organism
-	Streptomyces coelicolor

Protein Variants

Protein Variants	Comment	Organism
D100N	below 5% of wild-type activity	Streptomyces coelicolor
D99E	below 5% of wild-type activity	Streptomyces coelicolor
D99N	completely inactive	Streptomyces coelicolor
E248D	below 5% of wild-type activity	Streptomyces coelicolor
N240D	below 5% of wild-type activity	Streptomyces coelicolor
S244A	below 5% of wild-type activity	Streptomyces coelicolor

Metals/Ions

Metals/Ions	Comment	Organism	Structure
Mg2+	-	Streptomyces coelicolor

Organism

Organism	UniProt	Comment	Textmining
Streptomyces coelicolor	Q9K499	-	-
Streptomyces coelicolor A3(2)	Q9K499	-	-

Purification (Commentary)

Purification (Comment)	Organism
-	Streptomyces coelicolor

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
(2E,6E)-farnesyl diphosphate	-	Streptomyces coelicolor	(+)-epi-isozizaene + diphosphate	major product	?
(2E,6E)-farnesyl diphosphate	-	Streptomyces coelicolor A3(2)	(+)-epi-isozizaene + diphosphate	major product	?
(3R)-(Z)-nerolidyl diphosphate	>93:7 preference for (3R)-nerolidyl diphosphate over (3S)-nerolidyl diphosphate	Streptomyces coelicolor	(+)-epi-isozizaene + diphosphate	-	?
(3R)-(Z)-nerolidyl diphosphate	>93:7 preference for (3R)-nerolidyl diphosphate over (3S)-nerolidyl diphosphate	Streptomyces coelicolor A3(2)	(+)-epi-isozizaene + diphosphate	-	?

Synonyms

Synonyms	Comment	Organism
epi-isozizaene synthase	-	Streptomyces coelicolor
SCO5222 protein	-	Streptomyces coelicolor

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Release 2023.1 (January 2023)