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Literature summary for 4.2.3.182 extracted from

  • Klapschinski, T.A.; Rabe, P.; Dickschat, J.S.
    Pristinol, a sesquiterpene alcohol with an unusual skeleton from Streptomyces pristinaespiralis (2016), Angew. Chem. Int. Ed. Engl., 55, 10141-10144 .
    View publication on PubMed
Search for more literature for 4.2.3.182

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli Streptomyces pristinaespiralis

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
(2E,6E)-farnesyl diphosphate + H2O Streptomyces pristinaespiralis
-
 (+)-(2S,3R,9R)-pristinol + diphosphate
-
 ?
(2E,6E)-farnesyl diphosphate + H2O Streptomyces pristinaespiralis ATCC 25 486
-
 (+)-(2S,3R,9R)-pristinol + diphosphate
-
 ?
additional information Streptomyces pristinaespiralis possible reaction mechanisms start with the cyclization of farnesyl diphosphate to the humulyl cation, a 1,2-hydride shift, and capture with water to (R)-hyemalol. No substrates: geranyl diphosphate and geranylgeranyl diphosphate ?
-
 ?
additional information Streptomyces pristinaespiralis ATCC 25 486 possible reaction mechanisms start with the cyclization of farnesyl diphosphate to the humulyl cation, a 1,2-hydride shift, and capture with water to (R)-hyemalol. No substrates: geranyl diphosphate and geranylgeranyl diphosphate ?
-
 ?

Organism

Organism UniProt Comment Textmining
Streptomyces pristinaespiralis B5H7H3
-
-
Streptomyces pristinaespiralis ATCC 25 486 B5H7H3
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(2E,6E)-farnesyl diphosphate + H2O
-
 Streptomyces pristinaespiralis (+)-(2S,3R,9R)-pristinol + diphosphate
-
 ?
(2E,6E)-farnesyl diphosphate + H2O
-
 Streptomyces pristinaespiralis ATCC 25 486 (+)-(2S,3R,9R)-pristinol + diphosphate
-
 ?
additional information possible reaction mechanisms start with the cyclization of farnesyl diphosphate to the humulyl cation, a 1,2-hydride shift, and capture with water to (R)-hyemalol. No substrates: geranyl diphosphate and geranylgeranyl diphosphate Streptomyces pristinaespiralis ?
-
 ?
additional information possible reaction mechanisms start with the cyclization of farnesyl diphosphate to the humulyl cation, a 1,2-hydride shift, and capture with water to (R)-hyemalol. No substrates: geranyl diphosphate and geranylgeranyl diphosphate Streptomyces pristinaespiralis ATCC 25 486 ?
-
 ?

Synonyms

Synonyms Comment Organism
pentalenene synthase
-
 Streptomyces pristinaespiralis