Literature summary for 4.2.3.18 extracted from

Keeling, C.I.; Madilao, L.L.; Zerbe, P.; Dullat, H.K.; Bohlmann, J.
The primary diterpene synthase products of Picea abies levopimaradiene/abietadiene synthase (PaLAS) are epimers of a thermally unstable diterpenol (2011), J. Biol. Chem., 286, 21145-21153.

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Organism

Organism	UniProt	Comment	Textmining
Picea abies	-	bifunctional levopimaradiene/abietadiene synthase	-

Reaction

Reaction	Comment	Organism	Reaction ID
(+)-copalyl diphosphate = abieta-7,13-diene + diphosphate	reaction mechanism proceeds via water quenching of the abieta-8(14)-en-13-yl carbocation, resulting in 13-hydroxy-8(14)-abietene	Picea abies	a

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
(+)-copalyl diphosphate	-	Picea abies	(+-)-13-hydroxy-8(14)-abietene + diphosphate	initial product of the reaction, thermally unstable. Dehydration of the alcohol products of (+)-copalyl diphosphate, yielding the well established diterpene products levopimaradiene, abietadiene, neoabietadiene, and palustradiene, may occurr due to three conditions of the GC-MS analysis typically used for identification of diterpene synthase products: a hot injector, a hot oven temperature necessary for eluting the compounds, and the high temperature and high energy of the MS and its interface	?

Synonyms

Synonyms	Comment	Organism
PaLAS	-	Picea abies

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Release 2023.1 (January 2023)