Literature summary for 4.2.3.175 extracted from

Schifrin, A.; Khatri, Y.; Kirsch, P.; Thiel, V.; Schulz, S.; Bernhardt, R.
A single terpene synthase is responsible for a wide variety of sesquiterpenes in Sorangium cellulosum Soce56 (2016), Org. Biomol. Chem., 14, 3385-3393 .

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Cloned(Commentary)

Cloned (Comment)	Organism
expression in Escherichia coli	Sorangium cellulosum

Organism

Organism	UniProt	Comment	Textmining
Sorangium cellulosum	A9GK58	-	-
Sorangium cellulosum So ce56	A9GK58	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
(2E,6E)-farnesyl diphosphate + H2O	-	Sorangium cellulosum	10-epi-cubebol + diphosphate	-	?
(2E,6E)-farnesyl diphosphate + H2O	-	Sorangium cellulosum So ce56	10-epi-cubebol + diphosphate	-	?

Synonyms

Synonyms	Comment	Organism
sce6369	-	Sorangium cellulosum

General Information

General Information	Comment	Organism
physiological function	feeding mevalonolactone to a sce6369 expressing Escherichia coli strain results in a mixture of 21 sesquiterpene products. Structurally identified sesquiterpenes have all cadalane- and cubebane-type scaffolds with the exception of germacrene D. Main product is 10-epi-cubebol	Sorangium cellulosum

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Release 2023.1 (January 2023)