Literature summary for 4.2.3.17 extracted from

Jin, Y.; Williams, D.C.; Croteau, R.; Coates, R.M.
Taxadiene synthase-catalyzed cyclization of 6-fluorogeranylgeranyl diphosphate to 7-fluoroverticillenes (2005), J. Am. Chem. Soc., 127, 7834-7842.

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Organism

Organism	UniProt	Comment	Textmining
Taxus brevifolia	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
7-fluorogeranylgeranyl diphosphate	-	Taxus brevifolia	(1R,3E,7Z,11R)-7-fluoro-4,8,12,15,15-pentamethyl-bicyclo[9.3.1]pentadeca-3,7,12-triene	i.e. endo-7-fluoroverticillene, 25% yield	?
7-fluorogeranylgeranyl diphosphate	-	Taxus brevifolia	4(20)-methylene-7-fluoroverticillene	i.e. 4(20)-methylene-7-fluoroverticillene, 26% yield	?
7-fluorogeranylgeranyl diphosphate	verticille-12-yl carbocation intermediate with an 11R stereocenter, the reaction gives three main products and two further isomers	Taxus brevifolia	(1S,3E,7Z,11R)-7-fluoro-4,8,15,15-tetramethyl-12-methylene-bicyclo[9.3.1]pentadeca-3,7-diene	i.e. exo-7-fluoroverticillene, 37% yield	?

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Release 2023.1 (January 2023)