Application | Comment | Organism |
---|---|---|
medicine | chemotherapeutic agent against a range of cancers, including ovarian and breast cancer | Taxus brevifolia |
Cloned (Comment) | Organism |
---|---|
overexpression in Escherichia coli | Taxus brevifolia |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.003 | - |
geranylgeranyl diphosphate | native enzyme | Taxus brevifolia | |
0.0031 | - |
geranylgeranyl diphosphate | thioredoxin fusion | Taxus brevifolia | |
0.0105 | - |
geranylgeranyl diphosphate | M1 preprotein | Taxus brevifolia | |
0.014 | - |
geranylgeranyl diphosphate | M93 | Taxus brevifolia | |
0.0159 | - |
geranylgeranyl diphosphate | M79 | Taxus brevifolia |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
geranylgeranyl diphosphate | Taxus brevifolia | catalyzes the first step in taxol biosynthesis | taxa-4,11-diene + diphosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Taxus brevifolia | - |
- |
- |
Purification (Comment) | Organism |
---|---|
- |
Taxus brevifolia |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
cyclopropylidene | - |
Taxus brevifolia | ? | - |
? | |
geranylgeranyl diphosphate | - |
Taxus brevifolia | taxa-4(5),11(12)-diene + diphosphate | - |
? | |
geranylgeranyl diphosphate | taxa-4(20),11(12)-diene is formed as a small amount | Taxus brevifolia | taxa-4(20),11(12)-diene + diphosphate | - |
? | |
geranylgeranyl diphosphate | catalyzes the first step in taxol biosynthesis | Taxus brevifolia | taxa-4,11-diene + diphosphate | - |
? |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.00004 | - |
geranylgeranyl diphosphate | M1 preprotein | Taxus brevifolia | |
0.0000417 | - |
geranylgeranyl diphosphate | thioredoxin fusion | Taxus brevifolia | |
0.000133 | - |
geranylgeranyl diphosphate | M93 | Taxus brevifolia | |
0.00017 | - |
geranylgeranyl diphosphate | M79 | Taxus brevifolia | |
0.000177 | - |
geranylgeranyl diphosphate | native enzyme | Taxus brevifolia |