Application | Comment | Organism |
---|---|---|
medicine | chemotherapeutic agent against a range of cancers, including ovarian and breast cancer | Taxus brevifolia |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0026 | - |
geranylgeranyl diphosphate | - |
Taxus canadensis | |
0.025 | - |
Mg2+ | cofactor Mg2+ | Taxus canadensis |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | - |
Taxus canadensis |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
79000 | - |
79000, SDS-PAGE | Taxus canadensis |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
geranylgeranyl diphosphate | Taxus brevifolia | catalyzes the first step in taxol biosynthesis | taxa-4,11-diene + diphosphate | - |
? | |
geranylgeranyl diphosphate | Taxus canadensis | catalyzes the first step in taxol biosynthesis | taxa-4,11-diene + diphosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Taxus brevifolia | - |
- |
- |
Taxus canadensis | - |
- |
- |
Purification (Comment) | Organism |
---|---|
- |
Taxus canadensis |
Source Tissue | Comment | Organism | Textmining |
---|
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
0.0003 | - |
- |
Taxus canadensis |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
geranylgeranyl diphosphate | - |
Taxus brevifolia | taxa-4(5),11(12)-diene + diphosphate | - |
? | |
geranylgeranyl diphosphate | - |
Taxus canadensis | taxa-4(5),11(12)-diene + diphosphate | - |
? | |
geranylgeranyl diphosphate | catalyzes the first step in taxol biosynthesis | Taxus brevifolia | taxa-4,11-diene + diphosphate | - |
? | |
geranylgeranyl diphosphate | catalyzes the first step in taxol biosynthesis | Taxus canadensis | taxa-4,11-diene + diphosphate | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | 79000, SDS-PAGE | Taxus canadensis |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
8.5 | - |
- |
Taxus canadensis |