Literature summary for 4.2.3.160 extracted from

Rabe, P.; Rinkel, J.; Nubbemeyer, B.; Kollner, T.G.; Chen, F.; Dickschat, J.S.
Terpene cyclases from social amoebae (2016), Angew. Chem. Int. Ed. Engl., 55, 15420-15423.

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Organism

Organism	UniProt	Comment	Textmining
Dictyostelium discoideum	Q54P86	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
(2E,6E)-farnesyl diphosphate	no activity with geranyl diphosphate and geranylgeranyl diphosphate. The biosynthesis of (2S,3R,6S,9S)-(-)-protoillud-7-ene starts by 1,11-cyclization of (2E,6E)-farnesyl diphosphate to the humulyl cation. A 1,2-hydride shift and cyclization furnishes the protoilludyl cation that yields (2S,3R,6S,9S)-(-)-protoillud-7-ene upon deprotonation, while pentalenene is formed by dyotropic rearrangement and deprotonation	Dictyostelium discoideum	(2S,3R,6S,9S)-(-)-protoillud-7-ene + diphosphate	the major product is the sequiterpene (2S,3R,6S,9S)-()-protoillud-7-ene. Traces of pentalenene are also formed. (2S,3R,6S,9S)-()-protoillud-7-ene i.e. (2aS,4aS,7aS,7bR)-3,6,6,7b-tetramethyl-2,2a,4a,5,6,7,7a,7b-octahydro-1H-cyclobuta[e]indene	?

Synonyms

Synonyms	Comment	Organism
TPS6	-	Dictyostelium discoideum

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Release 2023.1 (January 2023)