Cloned (Comment) | Organism |
---|---|
expression in Escherichia coli | Streptomyces tsukubensis |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Streptomyces tsukubensis | I2N045 | - |
- |
Streptomyces tsukubensis NRRL 18488 | I2N045 | - |
- |
Purification (Comment) | Organism |
---|---|
- |
Streptomyces tsukubensis |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
geranylgeranyl diphosphate | tsukubadiene i.e. (1S,3aS,5Z,7aS,10aR,11Z)-1,5,8,8,10a-pentamethyl-2,3,3a,4,7,7a,8,9,10,10a-decahydro-1H-dicyclopenta[a,d][9]annulene. No activity with geranyl diphosphate and farnesyl diphosphate. Cyclization mechanism: The first elementary reaction proceeds by 1,11-Si-cyclization of geranylgeranyl diphosphate. In this step, the same absolute configuration at C11 is installed and is not changed during the further process | Streptomyces tsukubensis | tsukubadiene + diphosphate | - |
? | |
geranylgeranyl diphosphate | tsukubadiene i.e. (1S,3aS,5Z,7aS,10aR,11Z)-1,5,8,8,10a-pentamethyl-2,3,3a,4,7,7a,8,9,10,10a-decahydro-1H-dicyclopenta[a,d][9]annulene. No activity with geranyl diphosphate and farnesyl diphosphate. Cyclization mechanism: The first elementary reaction proceeds by 1,11-Si-cyclization of geranylgeranyl diphosphate. In this step, the same absolute configuration at C11 is installed and is not changed during the further process | Streptomyces tsukubensis NRRL 18488 | tsukubadiene + diphosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
TdS | - |
Streptomyces tsukubensis |