Protein Variants | Comment | Organism |
---|---|---|
additional information | a mutation Y841H, analogous to W753H mutation, can possibly lead to formation of verticillane | Taxus brevifolia |
W753H | the mutation leads to the exclusive formation of side product cembrene A. The simulations of the W753H mutant shows that, in the mutant structure, the His side chain is in the perfect position to deprotonate the cembrenyl cation en route to cembrene formation and that this abortive deprotonation is an energetically facile process | Taxus brevifolia |
Organism | UniProt | Comment | Textmining |
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Taxus brevifolia | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
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geranylgeranyl diphosphate | reaction of enzyme mutant W753H, cembrene A is only a side product for the wild-type enzyme | Taxus brevifolia | (R)-cembrene A + diphosphate | - |
? |