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Literature summary for 4.2.3.150 extracted from

  • Ansbacher, T.; Freud, Y.; Major, D.
    Slow-starter enzymes role of active-site architecture in the catalytic control of the biosynthesis of taxadiene by taxadiene synthase (2018), Biochemistry, 57, 3773-3779 .
    View publication on PubMed

Protein Variants

Protein Variants Comment Organism
additional information a mutation Y841H, analogous to W753H mutation, can possibly lead to formation of verticillane Taxus brevifolia
W753H the mutation leads to the exclusive formation of side product cembrene A. The simulations of the W753H mutant shows that, in the mutant structure, the His side chain is in the perfect position to deprotonate the cembrenyl cation en route to cembrene formation and that this abortive deprotonation is an energetically facile process Taxus brevifolia

Organism

Organism UniProt Comment Textmining
Taxus brevifolia
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
geranylgeranyl diphosphate reaction of enzyme mutant W753H, cembrene A is only a side product for the wild-type enzyme Taxus brevifolia (R)-cembrene A + diphosphate
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