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Literature summary for 4.2.3.133 extracted from

  • Guennewich, N.; Higashi, Y.; Feng, X.; Choi, K.B.; Schmidt, J.; Kutchan, T.M.
    A diterpene synthase from the clary sage Salvia sclarea catalyzes the cyclization of geranylgeranyl diphosphate to (8R)-hydroxy-copalyl diphosphate (2013), Phytochemistry, 91, 93-99.
    View publication on PubMed

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
89758
-
x * 89758, calulated Salvia sclarea

Organism

Organism UniProt Comment Textmining
Salvia sclarea J9PDV7
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
geranylgeranyl diphosphate + H2O it is proposed that a basic amino acid residue of the enzyme abstracts a proton from a molecule of water as the hydroxyl adds to the double bond at carbon7 of geranylgeranyl diphosphate. Concerted cyclization occurs and the double bond at carbon14 of geranylgeranyl diphosphate (carbon-3 of (8R)-hydroxy-copalyl diphosphate) is protonated. This concerted mechanism accounts for the addition of a single atom of 18O and a single atom of deuterium to geranylgeranyl diphosphate to form (8R)-hydroxy-copalyl diphosphate Salvia sclarea (13E)-8alpha-hydroxylabd-13-en-15-yl diphosphate first step in synthesis of sclareol ?

Subunits

Subunits Comment Organism
? x * 89758, calulated Salvia sclarea

Synonyms

Synonyms Comment Organism
TPS1
-
Salvia sclarea