Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
all-trans-heptaprenyl diphosphate | Alkalihalobacillus clausii | - |
tetraprenyl-beta-curcumene + diphosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Alkalihalobacillus clausii | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
all-trans-heptaprenyl diphosphate | - |
Alkalihalobacillus clausii | tetraprenyl-beta-curcumene + diphosphate | - |
? | |
additional information | Bcl-TS is a sesterterpene (C25)/triterpene (C30) synthase, the enzyme catalyzes the conversion of (all-E)-geranylfarnesyl diphosphate (GFPP) and (all-E)-hexaprenyl diphosphate (HexPP) into beta-geranylfarnesene and beta-hexaprene in a head-to-tail triterpene synthase. NMR spectroscopic and TLC analysis of radiolabeled products, overview. Enzyme Bcl-TS can accept HepPP (C35) as a substrate and cyclizes HepPP (C35) to a monocycle | Alkalihalobacillus clausii | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
Bcl-TS | - |
Alkalihalobacillus clausii |
sesterterpene/triterpene/sesquarterpene synthase | - |
Alkalihalobacillus clausii |
General Information | Comment | Organism |
---|---|---|
metabolism | GFPP and HexPP, the enzyme Bcl-TS substrates, are biosynthesized by enzymes E-IDS2-S/L in Bacillus clausii, and the tetraprenyl-beta-curcumene cyclase forms baciterpenol A from tetraprenyl-beta-curcumene. Proposed pathways for the biosynthesis of acyclic terpenes and menaquinones by Bacillus clausii, overview | Alkalihalobacillus clausii |
additional information | only one sesterterpene synthase (ophiobolin F synthase, EC 4.2.3.145) that utilizes GFPP as a substrate has been identified other than Bcl-TS to date | Alkalihalobacillus clausii |
physiological function | the tetraprenyl-beta-curcumene synthase homologue from Bacillus clausii (Bcl-TS) catalyzes the conversion of (all-E)-geranylfarnesyl diphosphate (GFPP) and (all-E)-hexaprenyl diphosphate (HexPP) into beta-geranylfarnesene and beta-hexaprene, respectively, in vitro, and both compounds are produced in Bacillus clausii. THe enzyme is involved in the biosynthesis of menaquinones | Alkalihalobacillus clausii |