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Literature summary for 4.2.3.130 extracted from

  • Sato, T.; Yoshida, S.; Hoshino, H.; Tanno, M.; Nakajima, M.; Hoshino, T.
    Sesquarterpenes (C35 terpenes) biosynthesized via the cyclization of a linear C35 isoprenoid by a tetraprenyl-beta-curcumene synthase and a tetraprenyl-beta-curcumene cyclase: identification of a new terpene cyclase (2011), J. Am. Chem. Soc., 133, 9734-9737.
    View publication on PubMed
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Cloned(Commentary)

Cloned (Comment) Organism
gene ytpB, expression as fusion protein in Escherichia coli strain BL21(DE3) from pColdTF. The ts gene or ytpB gene forms an operon with a lysophospholipase gene ytpA, which is responsible for the biosynthesis of the antibiotic bacilysocin in Bacillus subtilis Bacillus subtilis

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
all-trans-heptaprenyl diphosphate Bacillus subtilis
-
 tetraprenyl-beta-curcumene + diphosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Bacillus subtilis
-
 gene ytpB or ts
-

Purification (Commentary)

Purification (Comment) Organism
recombinant fusion protein YtpB from Escherichia coli strain BL21(DE3) by affinity chromatography Bacillus subtilis

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
all-trans-heptaprenyl diphosphate
-
 Bacillus subtilis tetraprenyl-beta-curcumene + diphosphate
-
 ?
all-trans-heptaprenyl diphosphate
-
 Bacillus subtilis tetraprenyl-beta-curcumene + diphosphate tetraprenyl-beta-curcumene shows nonenzymatic autooxidation to tetraprenyl-alpha-curcumene ?

Synonyms

Synonyms Comment Organism
ytpB
-
 Bacillus subtilis

General Information

General Information Comment Organism
additional information the ts gene or ytpB gene forms an operon with a lysophospholipase gene ytpA, which is responsible for the biosynthesis of the antibiotic bacilysocin in Bacillus subtilis Bacillus subtilis