Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Co2+ | required | Niallia circulans |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
D-glucose 6-phosphate | Niallia circulans | carbocycle formation | 2-deoxy-L-scyllo-inosose + phosphate | - |
? | |
D-glucose 6-phosphate | Niallia circulans SANK72073 | carbocycle formation | 2-deoxy-L-scyllo-inosose + phosphate | - |
? | |
additional information | Niallia circulans | the hydroxy group at C-4 is essential for enzyme activity, while the hydroxy groups at C-2 and C-3 are significant for efficial transformation of natural glucose 6-phosphate, but not essential for the reaction catalysis at the active site of enzyme, no activity with 4-deoxy-glucose 6-phosphate, substrate specificity, overview | ? | - |
? | |
additional information | Niallia circulans SANK72073 | the hydroxy group at C-4 is essential for enzyme activity, while the hydroxy groups at C-2 and C-3 are significant for efficial transformation of natural glucose 6-phosphate, but not essential for the reaction catalysis at the active site of enzyme, no activity with 4-deoxy-glucose 6-phosphate, substrate specificity, overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Niallia circulans | Q9S5E2 | - |
- |
Niallia circulans SANK72073 | Q9S5E2 | - |
- |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
D-glucose 6-phosphate = 2-deoxy-L-scyllo-inosose + phosphate | catalyric reaction mechanism and substrate specificity, overview | Niallia circulans |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
2-deoxy-D-glucose 6-phosphate | low activity | Niallia circulans | 2,5-dideoxy-L-scyllo-inosose + phosphate | - |
? | |
2-deoxy-D-glucose 6-phosphate | low activity | Niallia circulans SANK72073 | 2,5-dideoxy-L-scyllo-inosose + phosphate | - |
? | |
3-deoxy-D-glucose 6-phosphate | low activity | Niallia circulans | 2,4-dideoxy-L-scyllo-inosose + phosphate | - |
? | |
3-deoxy-D-glucose 6-phosphate | low activity | Niallia circulans SANK72073 | 2,4-dideoxy-L-scyllo-inosose + phosphate | - |
? | |
D-glucose 6-phosphate | carbocycle formation | Niallia circulans | 2-deoxy-L-scyllo-inosose + phosphate | - |
? | |
D-glucose 6-phosphate | carbocycle formation | Niallia circulans SANK72073 | 2-deoxy-L-scyllo-inosose + phosphate | - |
? | |
additional information | the hydroxy group at C-4 is essential for enzyme activity, while the hydroxy groups at C-2 and C-3 are significant for efficial transformation of natural glucose 6-phosphate, but not essential for the reaction catalysis at the active site of enzyme, no activity with 4-deoxy-glucose 6-phosphate, substrate specificity, overview | Niallia circulans | ? | - |
? | |
additional information | substrate specificity of 2-deoxy-scyllo-inosose synthase towards deoxyglucose 6-phosphates and proposed mechanism | Niallia circulans | ? | - |
? | |
additional information | the hydroxy group at C-4 is essential for enzyme activity, while the hydroxy groups at C-2 and C-3 are significant for efficial transformation of natural glucose 6-phosphate, but not essential for the reaction catalysis at the active site of enzyme, no activity with 4-deoxy-glucose 6-phosphate, substrate specificity, overview | Niallia circulans SANK72073 | ? | - |
? | |
additional information | substrate specificity of 2-deoxy-scyllo-inosose synthase towards deoxyglucose 6-phosphates and proposed mechanism | Niallia circulans SANK72073 | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
DOIS | - |
Niallia circulans |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Niallia circulans |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NAD+ | required | Niallia circulans |
General Information | Comment | Organism |
---|---|---|
metabolism | 2-deoxy-scyllo-inosose synthase is the starter enzyme for 2-deoxystreptamine biosynthesis. 2-Deoxystreptamine is the aglycon of clinically important aminocyclitol antibiotics | Niallia circulans |