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Literature summary for 4.2.3.118 extracted from

  • Kschowak, M.J.; Wortmann, H.; Dickschat, J.S.; Schrader, J.; Buchhaupt, M.
    Heterologous expression of 2-methylisoborneol / 2 methylenebornane biosynthesis genes in Escherichia coli yields novel C11-terpenes (2018), PLoS ONE, 13, e0196082 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 4.2.3.118

Protein Variants

Protein Variants Comment Organism
additional information usage of Escherichia coli strain MG1655 and derivatives for heterologous production of different C11-terpene synthases together with the GPP methyltransferase and the mevalonate pathway enzymes, 35 different C11-terpenes can be produced, overview Streptomyces coelicolor
additional information usage of Escherichia coli strain MG1655 and derivatives for heterologous production of different C11-terpene synthases together with the GPP methyltransferase and the mevalonate pathway enzymes, 35 different C11-terpenes can be produced, overview Streptomyces griseus subsp. griseus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
(E)-2-methylgeranyl diphosphate + H2O Streptomyces coelicolor
-
 2-methylisoborneol + diphosphate
-
 ?
(E)-2-methylgeranyl diphosphate + H2O Streptomyces griseus subsp. griseus
-
 2-methylisoborneol + diphosphate
-
 ?
(E)-2-methylgeranyl diphosphate + H2O Streptomyces coelicolor ATCC BAA-471 / A3(2) / M145
-
 2-methylisoborneol + diphosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Streptomyces coelicolor Q9F1Y6
-
-
Streptomyces coelicolor ATCC BAA-471 / A3(2) / M145 Q9F1Y6
-
-
Streptomyces griseus subsp. griseus Q9F1V8
-
-

Reaction

Reaction Comment Organism Reaction ID
(E)-2-methylgeranyl diphosphate + H2O = 2-methylisoborneol + diphosphate catalytic mechanism, overview Streptomyces coelicolor
a
(E)-2-methylgeranyl diphosphate + H2O = 2-methylisoborneol + diphosphate catalytic mechanism, overview Streptomyces griseus subsp. griseus
a

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(E)-2-methylgeranyl diphosphate + H2O
-
 Streptomyces coelicolor 2-methylisoborneol + diphosphate
-
 ?
(E)-2-methylgeranyl diphosphate + H2O
-
 Streptomyces griseus subsp. griseus 2-methylisoborneol + diphosphate
-
 ?
(E)-2-methylgeranyl diphosphate + H2O
-
 Streptomyces coelicolor ATCC BAA-471 / A3(2) / M145 2-methylisoborneol + diphosphate
-
 ?

Synonyms

Synonyms Comment Organism
2-MIB synthase
-
 Streptomyces coelicolor
2-MIB synthase
-
 Streptomyces griseus subsp. griseus
MIBSg
-
 Streptomyces coelicolor
MIBSg
-
 Streptomyces griseus subsp. griseus

General Information

General Information Comment Organism
physiological function 2-methylisoborneol (2-MIB) has a muddy smell with a low odor and flavor threshold and is a contaminant of drinking water, wine and fish. Moreover it is related to the musty-earthy aroma in camembert and brie Streptomyces coelicolor
physiological function 2-methylisoborneol (2-MIB) has a muddy smell with a low odor and flavor threshold and is a contaminant of drinking water, wine and fish. Moreover it is related to the musty-earthy aroma in camembert and brie Streptomyces griseus subsp. griseus