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Literature summary for 4.2.2.8 extracted from

  • Raman, K.; Kuberan, B.
    Differential effects of heparitinase I and heparitinase III on endothelial tube formation in vitro (2010), Biochem. Biophys. Res. Commun., 398, 191-193.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 4.2.2.8

Organism

Organism UniProt Comment Textmining
Pedobacter heparinus
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Source Tissue

Source Tissue Comment Organism Textmining
additional information propagated in bovine lung microvascular endothelial cells Pedobacter heparinus
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Synonyms

Synonyms Comment Organism
Hep I
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 Pedobacter heparinus
heparin lyase
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 Pedobacter heparinus
heparitinase I
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 Pedobacter heparinus

General Information

General Information Comment Organism
physiological function differential effects of heparitinase I and heparitinase III, EC 4.2.2.7, on endothelial tube formation. The enzymes inhibit tube formation and reduce tumor-derived neovascularization in vivo by reducing bFGF binding and subsequent signaling, HepIII has a stronger effect than Hep I. Heparitinases, isolated from Flavobacterium heparinum, cleave heparan sulfate chains at defined locations, Hep I cleaves heparin sulfate chains containing glucuronic acid residues adjacent to glucosamine residues containing either N-acetyl or N-sulfate groups. Hep I generates fragments that retain their growth factor binding capability and therefore still potentiate tube formation Pedobacter heparinus