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Literature summary for 4.2.2.7 extracted from

  • Bohlmann, L.; Chang, C.W.; Beacham, I.; von Itzstein, M.
    Exploring bacterial heparinase II activities with defined substrates (2015), ChemBioChem, 16, 1205-1211 .
    View publication on PubMed

Organism

Organism UniProt Comment Textmining
Bacteroides eggerthii E5X103
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-
Bacteroides eggerthii 1_2_48FAA E5X103
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Pedobacter heparinus
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-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
fondaparinux pentasaccharide, cleavage occurs by an eliminative mechanism and leads to the formation of a trisaccharide unit and a double-bond-containing disaccharide unit Pedobacter heparinus ?
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?
fondaparinux pentasaccharide, cleavage occurs by an eliminative mechanism and leads to the formation of a trisaccharide unit and a double-bond-containing disaccharide unit Bacteroides eggerthii ?
-
?
fondaparinux pentasaccharide, cleavage occurs by an eliminative mechanism and leads to the formation of a trisaccharide unit and a double-bond-containing disaccharide unit Bacteroides eggerthii 1_2_48FAA ?
-
?
additional information enzyme is able to cleave variants of fondaparinux which lack the glucosaminsulfate at the reducing end or have an addtional glucuronic acid or iduronic acid at the reducing end Pedobacter heparinus ?
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?
additional information enzyme is not able to cleave a variant of fondaparinux which lacks the glucosaminsulfate at the reducing end. Cleavage occurs with low activity in fondaparinux variants having an addtional glucuronic acid or iduronic acid at the reducing end Bacteroides eggerthii ?
-
?
additional information enzyme is not able to cleave a variant of fondaparinux which lacks the glucosaminsulfate at the reducing end. Cleavage occurs with low activity in fondaparinux variants having an addtional glucuronic acid or iduronic acid at the reducing end Bacteroides eggerthii 1_2_48FAA ?
-
?

Synonyms

Synonyms Comment Organism
heparinase II
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Pedobacter heparinus
heparinase II
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Bacteroides eggerthii
HMPREF1016_02668 locus name Bacteroides eggerthii