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Literature summary for 4.2.2.20 extracted from
- Chondroitinase ABC promotes sprouting of intact and injured spinal systems after spinal cord injury (2006), J. Neurosci., 26, 10856-10867.
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | cervical dorsal column injury and treatment with chondroitinase ABC treatment leads to robust sprouting of both injured and intact descending projections as well as uninjured primary afferents. Enzyme treatment of uninjured animals does not induce sprouting in any system, so both denervation and chondroitin sulfate proteoglycan degradation are required to promote sprouting within the spinal cord. No increase in connectivity of nociceptive neurons or development of mechanical allodynia or thermal hyperalgesia | Rattus norvegicus |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| spinal cord | - |
Rattus norvegicus | - |
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