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Literature summary for 4.2.1.94 extracted from

  • Butler, M.J.; Lazarovits, G.; Higgins, V.J.; Lachance, M.A.
    Partial purification and characterization of a dehydratase associated with the pentaketide melanogenesis pathway of Phaeococcomyces sp. and other fungi (1988), Exp. Mycol., 12, 367-376.
No PubMed abstract available
Search for more literature for 4.2.1.94

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2
-
 Scytalone 25°C Phaeococcomyces sp.

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
63000
-
 PAGE Phaeococcomyces sp.

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
scytalone Alternaria solani
-
 1,3,8-trihydroxynaphthalene + H2O
-
 ?
scytalone Verticillium albo-atrum
-
 1,3,8-trihydroxynaphthalene + H2O
-
 ?
scytalone Verticillium dahliae
-
 1,3,8-trihydroxynaphthalene + H2O
-
 ?
scytalone Phaeococcomyces sp.
-
 1,3,8-trihydroxynaphthalene + H2O
-
 ?
scytalone Cladosporium cucumerinum
-
 1,3,8-trihydroxynaphthalene + H2O
-
 ?

Organism

Organism UniProt Comment Textmining
Alternaria solani
-
-
-
Cladosporium cucumerinum
-
-
-
no activity in yeast extracts that do not form pentaketide melanins
-
-
-
Phaeococcomyces sp.
-
-
-
Verticillium albo-atrum
-
 not in extracts from organisms that had not yet formed melanin
-
Verticillium dahliae
-
 not in extracts from organisms that had not yet formed melanin
-

Posttranslational Modification

Posttranslational Modification Comment Organism
no modification no glycoprotein Phaeococcomyces sp.

Purification (Commentary)

Purification (Comment) Organism
partial Phaeococcomyces sp.

Storage Stability

Storage Stability Organism
-20°C, stable for 3 months Phaeococcomyces sp.

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
scytalone
-
 Alternaria solani 1,3,8-trihydroxynaphthalene + H2O
-
 ?
scytalone
-
 Verticillium albo-atrum 1,3,8-trihydroxynaphthalene + H2O
-
 ?
scytalone
-
 Verticillium dahliae 1,3,8-trihydroxynaphthalene + H2O
-
 ?
scytalone
-
 Phaeococcomyces sp. 1,3,8-trihydroxynaphthalene + H2O
-
 ?
scytalone
-
 Cladosporium cucumerinum 1,3,8-trihydroxynaphthalene + H2O
-
 ?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
 maximal activity under anaerobic conditions Phaeococcomyces sp.

pH Range

pH Minimum pH Maximum Comment Organism
6.5 8 pH 6.5: about 65% of maximum activity, pH 8: about 60% of maximum activity Phaeococcomyces sp.