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Literature summary for 4.2.1.9 extracted from

  • Gao, H.; Azam, T.; Randeniya, S.; Couturier, J.; Rouhier, N.; Johnson, M.K.
    Function and maturation of the Fe-S center in dihydroxyacid dehydratase from Arabidopsis (2018), J. Biol. Chem., 293, 4422-4433 .
    View publication on PubMedView publication on EuropePMC
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Organism

Organism UniProt Comment Textmining
Arabidopsis thaliana Q9LIR4
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Cofactor

Cofactor Comment Organism Structure
[2Fe-2S]-center DHAD can accommodate [Fe2S2] and [Fe4S4] clusters. Only the [Fe2S2] cluster-bound form is catalytically active. The [Fe2S2] cluster is coordinated by at least one non-cysteinyl ligand, which can be replaced by the thiol group(s) of dithiothreitol. [Fe2S2] cluster-containing NFU2 protein is likely the physiological cluster donor for in vivo maturation of DHAD Arabidopsis thaliana