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Literature summary for 4.2.1.9 extracted from
- Characterization and modification of enzymes in the 2-ketoisovalerate biosynthesis pathway of Ralstonia eutropha H16 (2015), Appl. Microbiol. Biotechnol., 99, 761-774 .
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expression in Escherichia coli | Cupriavidus necator |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| L-leucine | - |
Cupriavidus necator |  |
| L-valine | - |
Cupriavidus necator | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 2.7 | - |
2,3-dihydroxyisovalerate | pH 7.0, 30°C | Cupriavidus necator | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Cupriavidus necator | Q0K7F8 | - |
- |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 3.4 | - |
pH 7.0, 30°C | Cupriavidus necator |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 2,3-dihydroxyisovalerate | - |
Cupriavidus necator | 2-oxoisovalerate + H2O | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| DHAD | - |
Cupriavidus necator |
| H16_A2987 | locus name | Cupriavidus necator |
| IlvD | - |
Cupriavidus necator |
IC50 Value
| IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|
| 128 | - |
pH 7.0, 30°C | Cupriavidus necator | L-leucine | |
| 131 | - |
pH 7.0, 30°C | Cupriavidus necator | L-valine | |
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Release 2023.1 (January 2023)
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