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Literature summary for 4.2.1.9 extracted from
- Mechanism and stereochemistry of alpha,beta-dihydroxyacid dehydratase (1991), J. Am. Chem. Soc., 113, 1020-1025.
No PubMed abstract available
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.33 | - |
(2R,3R)-2,3-dihydroxy-3-methylpentanoate | - |
Spinacia oleracea |  |
| 0.55 | - |
2,3-dihydroxybutanoate | - |
Spinacia oleracea | |
| 0.71 | - |
(2R,3S)-2,3-dihydroxy-3-methylpentanoate | - |
Spinacia oleracea | |
| 0.97 | - |
2,3-Dihydroxy-3-methylbutanoate | - |
Spinacia oleracea | |
| 1.78 | - |
3-cyclopropyl-2,3-dihydroxybutanoate | - |
Spinacia oleracea | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Spinacia oleracea | - |
- |
- |
Reaction
| Reaction | Comment | Organism | Reaction ID |
|---|---|---|---|
| 2,3-dihydroxy-3-methylbutanoate = 3-methyl-2-oxobutanoate + H2O | polar but concerted elimination mechanism which should proceed through an anti transition state | Spinacia oleracea |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| (2R,3R)-2,3-dihydroxy-3-methylpentanoate | - |
Spinacia oleracea | 3-methyl-2-oxopentanoate + H2O | - |
? | |
| (2R,3S)-2,3-dihydroxy-3-methylpentanoate | - |
Spinacia oleracea | 3-methyl-2-oxopentanoate + H2O | - |
? | |
| 2,3-dihydroxy-3-methylbutanoate | - |
Spinacia oleracea | 2-oxoisovalerate + H2O | - |
? | |
| 2,3-dihydroxy-3-methylpentanoate | 2R,3S-2,3-dihydroxy-3-methylpentanoate, 2R,3R-2,3-dihydroxy-3-methylpentanoate | Spinacia oleracea | 3-methyl-2-oxopentanoate + H2O | - |
? | |
| 2,3-dihydroxybutanoate | - |
Spinacia oleracea | ? | - |
? | |
| 3-cyclopropyl-2,3-dihydroxybutanoate | - |
Spinacia oleracea | ? | - |
? | |
Turnover Number [1/s]
| Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 4.6 | - |
2,3-dihydroxybutanoate | - |
Spinacia oleracea | |
| 5.7 | - |
3-cyclopropyl-2,3-dihydroxybutanoate | - |
Spinacia oleracea | |
| 8.3 | - |
(2R,3R)-2,3-dihydroxy-3-methylpentanoate | - |
Spinacia oleracea | |
| 11.5 | - |
2,3-Dihydroxy-3-methylbutanoate | - |
Spinacia oleracea | |
| 12.3 | - |
(2R,3R)-2,3-dihydroxy-3-methylpentanoate | - |
Spinacia oleracea | |
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