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Literature summary for 4.2.1.9 extracted from

  • Limberg, G.; Klaffke, W.; Thiem, J.
    Conversion of aldonic acids to their corresponding 2-keto-3-deoxy-analogs by the non-carbohydrate enzyme dihydroxy acid dehydratase (DHAD) (1995), Bioorg. Med. Chem., 3, 487-494.
    View publication on PubMed
Search for more literature for 4.2.1.9

Inhibitors

Inhibitors Comment Organism Structure
2,4,5,6-tetrahydroxyhexanoate
-
 Spinacia oleracea
2,4,5-trihydroxypentanoate
-
 Spinacia oleracea
2,4-dihydroxybutanoate
-
 Spinacia oleracea

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.65
-
 L-threonate
-
 Spinacia oleracea
1.75
-
 D-erythronate
-
 Spinacia oleracea

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2,3-dihydroxy-3-methylpentanoate Spinacia oleracea involved in synthesis of Ile ?
-
 ?
2,3-dihydroxyisovalerate Spinacia oleracea involved in biosynthesis of Val ?
-
 ?

Organism

Organism UniProt Comment Textmining
Spinacia oleracea
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Spinacia oleracea

Source Tissue

Source Tissue Comment Organism Textmining
leaf
-
 Spinacia oleracea
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.132
-
-
 Spinacia oleracea

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2,3-dihydroxy-3-methylbutanoate
-
 Spinacia oleracea 2-oxoisovalerate + H2O
-
 ?
2,3-dihydroxy-3-methylpentanoate
-
 Spinacia oleracea 3-methyl-2-oxopentanoate + H2O
-
 ?
2,3-dihydroxy-3-methylpentanoate involved in synthesis of Ile Spinacia oleracea ?
-
 ?
2,3-dihydroxyisovalerate involved in biosynthesis of Val Spinacia oleracea ?
-
 ?
D-erythronate
-
 Spinacia oleracea ?
-
 ?
L-threonate
-
 Spinacia oleracea ?
-
 ?