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Literature summary for 4.2.1.9 extracted from

  • Flint, D.H.; Smyk-Randall, E.; Tuminello, J.F.; Draczynska-Lusiak, B.; Brown, O.R.
    The inactivation of dihydroxy-acid dehydratase in Escherichia coli treated with hyperbaric oxygen occurs because of the destruction of its Fe-S cluster, but the enzyme remains in the cell in a form that can be reactivated (1993), J. Biol. Chem., 268, 25547-25552.
    View publication on PubMed

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
-
-

Oxidation Stability

Oxidation Stability Organism
inactivation by exposure to hyperbaric O2 is due to the destruction of its catalytically active 4Fe-4S cluster. Reactivation occurs by reconstitution of the enzyme's Fe-S cluster Escherichia coli

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2,3-dihydroxy-3-methylbutanoate
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Escherichia coli 2-oxoisovalerate + H2O
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?
2,3-dihydroxy-3-methylpentanoate
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Escherichia coli 3-methyl-2-oxopentanoate + H2O
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?