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Literature summary for 4.2.1.78 extracted from

  • Ruff, B.M.; Braese, S.; O'Connor, S.E.
    Biocatalytic production of tetrahydroisoquinolines (2012), Tetrahedron Lett., 53, 1071-1074.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 4.2.1.78

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli BL21(DE3) cells Thalictrum flavum

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4-hydroxyphenylacetaldehyde + dopamine Thalictrum flavum 60% conversion after 3 h (S)-norcoclaurine + H2O
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 ?

Organism

Organism UniProt Comment Textmining
Thalictrum flavum
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-
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Purification (Commentary)

Purification (Comment) Organism
nickel resin column chromatography Thalictrum flavum

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(2-fluorophenyl)acetaldehyde + dopamine 65% conversion after 3 h Thalictrum flavum (1S)-1-[2-(2-fluorophenyl)ethyl]-1,2,3,4-tetrahydroisoquinoline-6,7-diol + H2O
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 ?
(2-methylphenyl)acetaldehyde + dopamine 66% conversion after 3 h Thalictrum flavum (1S)-1-[2-(2-methylphenyl)ethyl]-1,2,3,4-tetrahydroisoquinoline-6,7-diol + H2O
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 ?
(3,4-dimethoxyphenyl)acetaldehyde + dopamine 69% conversion after 3 h Thalictrum flavum (1S)-1-[2-(3,4-dimethoxyphenyl)ethyl]-1,2,3,4-tetrahydroisoquinoline-6,7-diol + H2O
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 ?
(3-fluorophenyl)acetaldehyde + dopamine 66% conversion after 3 h Thalictrum flavum (1S)-1-[2-(3-fluorophenyl)ethyl]-1,2,3,4-tetrahydroisoquinoline-6,7-diol + H2O
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 ?
(3-methylphenyl)acetaldehyde + dopamine 58% conversion after 3 h Thalictrum flavum (1S)-1-[2-(3-methylphenyl)ethyl]-1,2,3,4-tetrahydroisoquinoline-6,7-diol + H2O
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 ?
(4-fluorophenyl)acetaldehyde + dopamine 71% conversion after 3 h Thalictrum flavum (1S)-1-[2-(4-fluorophenyl)ethyl]-1,2,3,4-tetrahydroisoquinoline-6,7-diol + H2O
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 ?
(4-methoxyphenyl)acetaldehyde + dopamine 69% conversion after 3 h Thalictrum flavum (1S)-1-[2-(4-methoxyphenyl)ethyl]-1,2,3,4-tetrahydroisoquinoline-6,7-diol + H2O
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 ?
(4-methylphenyl)acetaldehyde + dopamine 57% conversion after 3 h Thalictrum flavum (1S)-1-[2-(4-fluorophenyl)ethyl]-1,2,3,4-tetrahydroisoquinoline-6,7-diol + H2O
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 ?
(5,5-dimethyl-1,3-dioxan-2-yl)acetaldehyde + dopamine 42% conversion after 3 h Thalictrum flavum (1S)-1-[2-(5,5-dimethyl-1,3-dioxan-2-yl)ethyl]-1,2,3,4-tetrahydroisoquinoline-6,7-diol + H2O
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 ?
3,3-dimethylbutanal + dopamine 52% conversion after 3 h Thalictrum flavum (1S)-1-(3,3-dimethylbutyl)-1,2,3,4-tetrahydroisoquinoline-6,7-diol + H2O
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 ?
4-hydroxyphenylacetaldehyde + dopamine 60% conversion after 3 h Thalictrum flavum (S)-norcoclaurine + H2O
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 ?
cyclohexylacetaldehyde + dopamine 71% conversion after 3 h Thalictrum flavum (1S)-1-(2-cyclohexylethyl)-1,2,3,4-tetrahydroisoquinoline-6,7-diol + H2O
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 ?
naphthalen-1-ylacetaldehyde + dopamine 61% conversion after 3 h Thalictrum flavum (1S)-1-[2-(naphthalen-1-yl)ethyl]-1,2,3,4-tetrahydroisoquinoline-6,7-diol + H2O
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 ?
phenylacetaldehyde + dopamine 51% conversion after 3 h Thalictrum flavum (1S)-1-(2-phenylethyl)-1,2,3,4-tetrahydroisoquinoline-6,7-diol + H2O
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 ?
thiophen-3-ylacetaldehyde + dopamine 68% conversion after 3 h Thalictrum flavum (1S)-1-[2-(thiophen-3-yl)ethyl]-1,2,3,4-tetrahydroisoquinoline-6,7-diol + H2O
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 ?
[4-(trifluoromethoxy)phenyl]acetaldehyde + dopamine 65% conversion after 3 h Thalictrum flavum (1S)-1-[2-[4-(trifluoromethoxy)phenyl]ethyl]-1,2,3,4-tetrahydroisoquinoline-6,7-diol + H2O
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 ?

Synonyms

Synonyms Comment Organism
NCS
-
 Thalictrum flavum