Literature summary for 4.2.1.70 extracted from

Bruni, C.B.; Colantuoni, V.; Sbordone, L.; Cortese, R.; Blasi, F.
Biochemical and regulatory properties of Escherichia coli K-12 hisT mutants (1977), J. Bacteriol., 130, 4-10.

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Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
additional information	Escherichia coli	mutation of the genlocus hisT causes lack of pseudouridylate synthetase activity. The defect in this enzyme leads to the absence of pseudouridines in the anticodon loop of several tRNA species	?	-	?

Organism

Organism	UniProt	Comment	Textmining
Escherichia coli	-	K-12	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
additional information	mutation of the genlocus hisT causes lack of pseudouridylate synthetase activity. The defect in this enzyme leads to the absence of pseudouridines in the anticodon loop of several tRNA species	Escherichia coli	?	-	?
uracil + D-ribose 5-phosphate	-	Escherichia coli	pseudouridine 5'-phosphate + H2O	-	?

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Release 2023.1 (January 2023)