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Literature summary for 4.2.1.51 extracted from

  • El-Azaz, J.; de la Torre, F.; Avila, C.; Canovas, F.M.
    Identification of a small protein domain present in all plant lineages that confers high prephenate dehydratase activity (2016), Plant J., 87, 215-229 .
    View publication on PubMed

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.15
-
prephenate pH 8.0, 37°C Pinus pinaster
0.3
-
prephenate pH 8.0, 37°C, prephenate dehydratase Cmut1 Pinus pinaster
0.34
-
prephenate pH 8.0, 37°C Pinus pinaster
2.11
-
prephenate pH 8.0, 37°C, prephenate dehydratase Gmut11 Pinus pinaster
2.15
-
prephenate pH 8.0, 37°C, prephenate dehydratase Gmut9 Pinus pinaster
2.72
-
prephenate pH 8.0, 37°C Pinus pinaster

Organism

Organism UniProt Comment Textmining
Pinus pinaster
-
-
-
Pinus pinaster A0A1I9WKA1
-
-
Pinus pinaster A0A1I9WKA2
-
-
Pinus pinaster A0A1I9WKA6
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
prephenate
-
Pinus pinaster phenylpyruvate + H2O + CO2
-
?

Synonyms

Synonyms Comment Organism
Cmut1
-
Pinus pinaster
Gmut11
-
Pinus pinaster
Gmut9
-
Pinus pinaster
PpADT-B
-
Pinus pinaster
PpADT-C
-
Pinus pinaster
PpADT-G
-
Pinus pinaster

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
0.031
-
prephenate pH 8.0, 37°C, prephenate dehydratase Cmut1 Pinus pinaster
0.036
-
prephenate pH 8.0, 37°C, prephenate dehydratase Gmut11 Pinus pinaster
0.04
-
prephenate pH 8.0, 37°C Pinus pinaster
0.04
-
prephenate pH 8.0, 37°C, prephenate dehydratase Gmut9 Pinus pinaster
0.3539
-
prephenate pH 8.0, 37°C Pinus pinaster
0.7158
-
prephenate pH 8.0, 37°C Pinus pinaster

General Information

General Information Comment Organism
evolution all plant clades include PAC domain-containing arogenate dehydratases, suggesting that the prephenate dehydratase activity, and thus the ability to synthesize L-phenylalanine using phenylpyruvate as an intermediate, has been preserved throughout the evolution of plants. This pathway together with the arogenate pathway gives plants a broad and versatile capacity to synthesize L-phenylalanine and its derived compounds Pinus pinaster
metabolism the enzyme is involved in the phenylpyruvate biosynthetic pathway Pinus pinaster

kcat/KM [mM/s]

kcat/KM Value [1/mMs-1] kcat/KM Value Maximum [1/mMs-1] Substrate Comment Organism Structure
14.7
-
prephenate pH 8.0, 37°C Pinus pinaster
17.14
-
prephenate pH 8.0, 37°C, prephenate dehydratase Gmut11 Pinus pinaster
18.6
-
prephenate pH 8.0, 37°C, prephenate dehydratase Gmut9 Pinus pinaster
103.3
-
prephenate pH 8.0, 37°C, prephenate dehydratase Cmut1 Pinus pinaster
1040.8
-
prephenate pH 8.0, 37°C Pinus pinaster
4772.1
-
prephenate pH 8.0, 37°C Pinus pinaster