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Literature summary for 4.2.1.47 extracted from

  • Yamamoto, K.; Katayama, I.; Onoda, Y.; Inami, M.; Kumagai, H.; Tochikura, T.
    Evidence that the enzyme catalyzing the conversion of guanosine diphosphate D-mannose to a 4-keto sugar nucleotide intermediate requires nicotinamide adenine dinucleotide phosphate (1993), Arch. Biochem. Biophys., 300, 694-698.
    View publication on PubMed
Search for more literature for 4.2.1.47

Inhibitors

Inhibitors Comment Organism Structure
GDP-L-fucose
-
 Klebsiella pneumoniae

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
42000
-
 2 * 42000 Klebsiella pneumoniae
110000
-
 gel filtration Klebsiella pneumoniae

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
GDPmannose Klebsiella pneumoniae
-
 ?
-
 ?

Organism

Organism UniProt Comment Textmining
Klebsiella pneumoniae
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Klebsiella pneumoniae

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
7.09
-
-
 Klebsiella pneumoniae

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
GDP-mannose
-
 Klebsiella pneumoniae GDP-4-dehydro-6-deoxy-D-mannose + H2O
-
 ?
GDPmannose
-
 Klebsiella pneumoniae ?
-
 ?

Subunits

Subunits Comment Organism
dimer 2 * 42000 Klebsiella pneumoniae

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
25
-
 assay at Klebsiella pneumoniae

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7 7.5
-
 Klebsiella pneumoniae

Cofactor

Cofactor Comment Organism Structure
NADP+ strict requirement, cannot be substituted by NAD+ Klebsiella pneumoniae