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Literature summary for 4.2.1.46 extracted from

  • Vara, J.A.; Hutchinson, C.R.
    Purification of thymidine-diphospho-D-glucose 4,6-dehydratase from an erythromycin-producing strain of Saccharospora erythraea by high resolution liquid chromatography (1988), J. Biol. Chem., 263, 14992-14995.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
TDP
-
Saccharopolyspora erythraea
TTP
-
Saccharopolyspora erythraea

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.019
-
NAD+
-
Saccharopolyspora erythraea
0.034
-
dTDPglucose
-
Saccharopolyspora erythraea

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
36000
-
2 * 36000, SDS-PAGE Saccharopolyspora erythraea
60000
-
gel filtration Saccharopolyspora erythraea

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
dTDP-glucose Saccharopolyspora erythraea key role in biosynthesis of macrolides and other types of antibiotics ?
-
?

Organism

Organism UniProt Comment Textmining
Saccharopolyspora erythraea
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Saccharopolyspora erythraea

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.4
-
dTDPglucose Saccharopolyspora erythraea

Storage Stability

Storage Stability Organism
50% loss of activity during storage at -20¦C or -80¦C for less than 1 week Saccharopolyspora erythraea

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
dTDP-glucose
-
Saccharopolyspora erythraea dTDP-4-dehydro-6-deoxy-D-glucose + H2O
-
?
dTDP-glucose key role in biosynthesis of macrolides and other types of antibiotics Saccharopolyspora erythraea ?
-
?

Subunits

Subunits Comment Organism
dimer 2 * 36000, SDS-PAGE Saccharopolyspora erythraea

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
dTDPglucose, assay at Saccharopolyspora erythraea

Cofactor

Cofactor Comment Organism Structure
NAD+
-
Saccharopolyspora erythraea