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Literature summary for 4.2.1.39 extracted from

  • Nunn, C.E.; Johnsen, U.; Schoenheit, P.; Fuhrer, T.; Sauer, U.; Hough, D.W.; Danson, M.J.
    Metabolism of pentose sugars in the hyperthermophilic archaea Sulfolobus solfataricus and Sulfolobus acidocaldarius (2010), J. Biol. Chem., 285, 33701-33709.
    View publication on PubMedView publication on EuropePMC

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
D-gluconate Saccharolobus solfataricus
-
2-dehydro-3-deoxy-D-gluconate + H2O
-
?
D-gluconate Saccharolobus solfataricus P2
-
2-dehydro-3-deoxy-D-gluconate + H2O
-
?
additional information Saccharolobus solfataricus gluconate dehydratase being active only with C6 metabolites ?
-
?
additional information Saccharolobus solfataricus P2 gluconate dehydratase being active only with C6 metabolites ?
-
?

Organism

Organism UniProt Comment Textmining
Saccharolobus solfataricus
-
-
-
Saccharolobus solfataricus P2
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
D-gluconate
-
Saccharolobus solfataricus 2-dehydro-3-deoxy-D-gluconate + H2O
-
?
D-gluconate
-
Saccharolobus solfataricus P2 2-dehydro-3-deoxy-D-gluconate + H2O
-
?
additional information gluconate dehydratase being active only with C6 metabolites Saccharolobus solfataricus ?
-
?
additional information gluconate dehydratase being active only with C6 metabolites Saccharolobus solfataricus P2 ?
-
?

General Information

General Information Comment Organism
metabolism the enzyme is involved in the non-phosphorylative version of the Entner-Doudoroff pathway, overview. In vitro kinetic analyses of glucose dehydrogenase, gluconate dehydratase, and KDG-aldolase from Sulfolobus solfataricus show, that these enzymes are also capable of catalyzing the catabolism of galactose, the C4 epimer of glucose, to pyruvate and glyceraldehyde. Gluconate dehydratase is active only with C6 metabolites, thus it is not involved in the C5-specific branch of the non-phosphorylative version of the Entner-Doudoroff pathway Saccharolobus solfataricus