Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 4.2.1.36 extracted from

  • Teves, F.; Lamas-Maceiras, M.; Garcia-Estrada, C.; Casqueiro, J.; Naranjo, L.; Ullan, R.V.; Scervino, J.M.; Wu, X.; Velasco-Conde, T.; Martin, J.F.
    Transcriptional upregulation of four genes of the lysine biosynthetic pathway by homocitrate accumulation in Penicillium chrysogenum: homocitrate as a sensor of lysine-pathway distress (2009), Microbiology, 155, 3881-3892.
    View publication on PubMed
Search for more literature for 4.2.1.36

Cloned(Commentary)

Cloned (Comment) Organism
lys3 from the parental strain Wis 54-1255 and lys3 mutant allele from strain L2, cloned into pBluescript KS(+) Penicillium chrysogenum
plasmid pLysF1 expressed in Penicillium chrysogenum L2 mutant strain Aspergillus nidulans

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
84490
-
 Wis 54-1255 gene lys3, sequence analysis Penicillium chrysogenum

Organism

Organism UniProt Comment Textmining
Aspergillus nidulans Q92412
-
-
Penicillium chrysogenum B1P2N4 strain Wis 54-1255 and strain L2
-

Source Tissue

Source Tissue Comment Organism Textmining
mycelium
-
 Penicillium chrysogenum
-

Synonyms

Synonyms Comment Organism
Homoaconitase
-
 Penicillium chrysogenum
Homoaconitase
-
 Aspergillus nidulans
lysF
-
 Aspergillus nidulans

Expression

Organism Comment Expression
Penicillium chrysogenum transcription of the lys3 gene shows a 3fold increase in the transcript level of this gene in strain L2 as compared with the parental strain Wis 54-1255 up

General Information

General Information Comment Organism
malfunction L2 mutant is deficient in homoaconitase activity since it is complemented by the Aspergillus nidulans lysF gene. Wis 54-1255 gene lys3 complements the L2 mutation. Accumulation of homocitric acid in the L2 strain, resulting from the mutation in the lys3 (homoaconitase) gene, is required for the upregulation of the lysine biosynthetic genes. The mutant Lys3 protein is altered in a region required to bind the [4Fe-4S] cluster Penicillium chrysogenum
physiological function lysF gene can complement the Penicillium chrysogenum L2 mutant deficient in homoaconitase activity Aspergillus nidulans