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Literature summary for 4.2.1.24 extracted from
- Cadmium inhibits delta-aminolevulinate dehydratase from rat lung in vitro: interaction with chelating and antioxidant agents (2007), Chem. Biol. Interact., 165, 127-137.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 2,3-dimercaptopropane-1-sulfonic acid | 0.1 mM, 20% inhibition, more pronounced inhibition in combination with Cd2+ | Rattus norvegicus |  |
| ascorbic acid | 0.4 mM, 23% inhibition | Rattus norvegicus | |
| Cd2+ | inhibits delta-ALA-D activity. Chelating and antioxidant agents potentiated the inhibition | Rattus norvegicus | |
| diphenyl diselenide | 0.0005 mM, 17% inhibition | Rattus norvegicus | |
| meso-2,3-dimercaptosuccinic acid | 0.1 mM, 18% inhibition | Rattus norvegicus | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| lung | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 5-aminolevulinate + 5-aminolevulinate | - |
Rattus norvegicus | porphobilinogen + 2 H2O | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| delta-ALA-D | - |
Rattus norvegicus |
IC50 Value
| IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|
| 0.0345 | - |
pH 6.8, 37°C | Rattus norvegicus | Cd2+ | |
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Release 2023.1 (January 2023)
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