Literature summary for 4.2.1.24 extracted from

Kundrat, L.; Martins, J.; Stith, L.; Dunbrack, R.L., Jr.; Jaffe, E.K.
A structural basis for half-of-the-sites metal binding revealed in Drosophila melanogaster porphobilinogen synthase (2003), J. Biol. Chem., 278, 31325-31330.

Search for more literature for 4.2.1.24

Cloned(Commentary)

Cloned (Comment)	Organism
-	Drosophila melanogaster

Protein Variants

Protein Variants	Comment	Organism
H10F	mutant enzyme is active but is not inhibited by zinc. H10F binds a catalytic zinc at 0.5/subunit and binds a second nonessential and noninhibitory zinc at 0.5/subunit	Drosophila melanogaster

Inhibitors

Inhibitors	Comment	Organism	Structure
Zn2+	the inhibitory zinc is located at a subunit interface using Cys219 and His10 as ligands	Drosophila melanogaster

KM Value [mM]

KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
0.108	-	5-aminolevulinate	pH 8	Drosophila melanogaster

Organism

Organism	UniProt	Comment	Textmining
Drosophila melanogaster	-	-	-

Purification (Commentary)

Purification (Comment)	Organism
-	Drosophila melanogaster

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg]	Specific Activity Maximum [µmol/min/mg]	Comment	Organism
0.283	-	-	Drosophila melanogaster

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
5-aminolevulinate + 5-aminolevulinate	-	Drosophila melanogaster	porphobilinogen + 2 H2O	-	?

Synonyms

Synonyms	Comment	Organism
PBGS	-	Drosophila melanogaster

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Release 2023.1 (January 2023)