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Literature summary for 4.2.1.24 extracted from
- Mechanism of porphobilinogen synthase. Requirement of Zn2+ for enzyme activity (1980), J. Biol. Chem., 255, 2030-2035.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 1,10-phenanthroline | - |
Bos taurus |  |
| 8-Hydroxyquinoline-5-sulfonic acid | - |
Bos taurus | |
| bathocuproine disulfonic acid | - |
Bos taurus | |
| EDTA | - |
Bos taurus | |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Cd2+ | can restore activity of the apoenzyme | Bos taurus | |
| Zn2+ | Zn2+ forms a bond with a sulfhydryl group in the enzyme, the octameric enzyme contains 4 gatom of Zn2+ per mol of enzyme, Zn2+ does not participate in substrate binding nor in the maintenance of the quarternary structure of the enzyme | Bos taurus | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Bos taurus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Bos taurus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 5-aminolevulinate + 5-aminolevulinate | - |
Bos taurus | porphobilinogen + 2 H2O | - |
? | |
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Release 2023.1 (January 2023)
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