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Literature summary for 4.2.1.24 extracted from

  • Jordan, P.M.; Seehra, J.S.
    Purification of porphobilinogen synthase from bovine liver (1986), Methods Enzymol., 123, 427-434.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
thiol 20 mM, essential to maintain the enzyme in its reduced state Bos taurus

Inhibitors

Inhibitors Comment Organism Structure
5-bromolevulinic acid
-
Bos taurus
5-chlorolevulinic acid
-
Bos taurus
5-iodolevulinic acid
-
Bos taurus
DTNB reversible loss of activity Bos taurus
EDTA
-
Bos taurus
iodoacetamide irreversible Bos taurus
iodoacetate irreversible Bos taurus
Mercury ions
-
Bos taurus
Pb2+
-
Bos taurus

Metals/Ions

Metals/Ions Comment Organism Structure
Zn2+ required Bos taurus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
35000
-
8 * 35000, SDS-PAGE Bos taurus
280000
-
gel filtration Bos taurus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
5-aminolevulinate Bos taurus
-
?
-
?

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-

Oxidation Stability

Oxidation Stability Organism
total but reversible loss of activity by O2 Bos taurus

Purification (Commentary)

Purification (Comment) Organism
-
Bos taurus

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Bos taurus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.63
-
-
Bos taurus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5-aminolevulinate
-
Bos taurus ?
-
?
5-aminolevulinate + 5-aminolevulinate
-
Bos taurus porphobilinogen + 2 H2O
-
?

Subunits

Subunits Comment Organism
octamer 8 * 35000, SDS-PAGE Bos taurus