Activating Compound | Comment | Organism | Structure |
---|---|---|---|
betaine | 1 M betaine activates the enzyme 1.8fold in the absence of monovalent cations | Salmonella enterica subsp. enterica serovar Typhimurium | |
polyethylene glycol 8000 | 5% (w/v) activates the enzyme 2.1fold in the absence of monovalent cations | Salmonella enterica subsp. enterica serovar Typhimurium | |
sucrose | 2 M sucrose activates the enzyme 3.3fold in the absence of monovalent cations | Salmonella enterica subsp. enterica serovar Typhimurium | |
taurine | 0.5 M taurine activates the enzyme 3fold in the absence of monovalent cations | Salmonella enterica subsp. enterica serovar Typhimurium |
Cloned (Comment) | Organism |
---|---|
expressed in Escherichia coli | Salmonella enterica subsp. enterica serovar Typhimurium |
General Stability | Organism |
---|---|
in the presence of monovalent cations, osmolytes have only minor effects on activity and allosteric equilibria, but 1 M betaine stabilizes the Trp synthase-L-Ser-indoline complex against apparent pressure-induced subunit dissociation | Salmonella enterica subsp. enterica serovar Typhimurium |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
K+ | activates at 0.1 M | Salmonella enterica subsp. enterica serovar Typhimurium | |
Na+ | activates at 0.1 M | Salmonella enterica subsp. enterica serovar Typhimurium | |
NH4+ | activates at 0.1 M | Salmonella enterica subsp. enterica serovar Typhimurium |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-serine + 1-C-(indol-3-yl)glycerol 3-phosphate | Salmonella enterica subsp. enterica serovar Typhimurium | - |
L-tryptophan + D-glyceraldehyde 3-phosphate + H2O | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Salmonella enterica subsp. enterica serovar Typhimurium | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-serine + 1-C-(indol-3-yl)glycerol 3-phosphate | - |
Salmonella enterica subsp. enterica serovar Typhimurium | L-tryptophan + D-glyceraldehyde 3-phosphate + H2O | - |
? |
Synonyms | Comment | Organism |
---|---|---|
Trp synthase | - |
Salmonella enterica subsp. enterica serovar Typhimurium |