Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 4.2.1.20 extracted from

  • Lai, J.; Niks, D.; Wang, Y.; Domratcheva, T.; Barends, T.R.; Schwarz, F.; Olsen, R.A.; Elliott, D.W.; Fatmi, M.Q.; Chang, C.E.; Schlichting, I.; Dunn, M.F.; Mueller, L.J.
    X-ray and NMR crystallography in an enzyme active site: the indoline quinonoid intermediate in tryptophan synthase (2011), J. Am. Chem. Soc., 133, 4-7.
    View publication on PubMed
Search for more literature for 4.2.1.20

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-serine + 1-C-(indol-3-yl)glycerol 3-phosphate Salmonella enterica
-
 L-tryptophan + glyceraldehyde 3-phosphate + H2O
-
 ?

Organism

Organism UniProt Comment Textmining
Salmonella enterica
-
-
-

Reaction

Reaction Comment Organism Reaction ID
L-serine + 1-C-(indol-3-yl)glycerol 3-phosphate = L-tryptophan + D-glyceraldehyde 3-phosphate + H2O catalytic mechanism via an indoline quinonoid intermediate, with importance of an equilibrium between tautomeric forms of the substrate, with the protonation state of the major isomer directing the next catalytic step, active site structure, and indoline and beta-site reactions by NMR spectroscopy, overview Salmonella enterica
a

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-serine + 1-C-(indol-3-yl)glycerol 3-phosphate
-
 Salmonella enterica L-tryptophan + glyceraldehyde 3-phosphate + H2O
-
 ?

Cofactor

Cofactor Comment Organism Structure
pyridoxal 5'-phosphate structure in complex with substrate, overview Salmonella enterica