Application | Comment | Organism |
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medicine | the degradation of cell membranes in connection with necrosis leads to elevated fumarase activity in plasma and urine and hyperpolarized [1,4-13C2]malate production 24 h after reperfusion correlates with renal necrosis in a 40-min unilateral ischemic rat model. Fumarase activity screening on bio-fluids can detect injury severity. After verification of renal injury by bio-fluid analysis the precise injury location can be monitored by in vivo measurements of the fumarase activity non-invasively by hyperpolarized [1,4-13C]fumarate magnetic resonance imaging | Rattus norvegicus |
Organism | UniProt | Comment | Textmining |
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Rattus norvegicus | - |
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