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Literature summary for 4.2.1.2 extracted from

  • Nielsen, P.M.; Eldirdiri, A.; Bertelsen, L.B.; Jorgensen, H.S.; Ardenkjaer-Larsen, J.H.; Laustsen, C.
    Fumarase activity an in vivo and in vitro biomarker for acute kidney injury (2017), Sci. Rep., 7, 40812 .
    View publication on PubMedView publication on EuropePMC

Application

Application Comment Organism
medicine the degradation of cell membranes in connection with necrosis leads to elevated fumarase activity in plasma and urine and hyperpolarized [1,4-13C2]malate production 24 h after reperfusion correlates with renal necrosis in a 40-min unilateral ischemic rat model. Fumarase activity screening on bio-fluids can detect injury severity. After verification of renal injury by bio-fluid analysis the precise injury location can be monitored by in vivo measurements of the fumarase activity non-invasively by hyperpolarized [1,4-13C]fumarate magnetic resonance imaging Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
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