Cloned (Comment) | Organism |
---|---|
expressed in HK-2 cells and in skin fibroblasts | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
E319Q | mutant with strongly reduced activity | Homo sapiens |
I77V | the mutant enzyme shows increased activity | Homo sapiens |
R190H | almost inactive mutant, the R190H missense mutation is the most frequent in hereditary leiomyomatosis and renal cell cancer patients | Homo sapiens |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
50000 | - |
4 * 50000, SDS-PAGE | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
fumarate + H2O | - |
Homo sapiens | L-malate | - |
? |
Subunits | Comment | Organism |
---|---|---|
homotetramer | 4 * 50000, SDS-PAGE | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
fumarase | - |
Homo sapiens |