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Literature summary for 4.2.1.19 extracted from

  • Bisson, C.; Britton, K.L.; Sedelnikova, S.E.; Rodgers, H.F.; Eadsforth, T.C.; Viner, R.C.; Hawkes, T.R.; Baker, P.J.; Rice, D.W.
    Crystal structures reveal that the reaction mechanism of imidazoleglycerol-phosphate dehydratase is controlled by switching Mn(II) coordination (2015), Structure, 23, 1236-1245 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 4.2.1.19

Crystallization (Commentary)

Crystallization (Comment) Organism
structure of isoform IGPD2 in complex with phosphate, to 1.75 A resolution. The holoenzyme has an open conformation where the C-terminal region (R193-R206, termed the C loop), which contains a number of conserved residues, is disordered. structure of mutant E21Q, to 1.12 A resolution Arabidopsis thaliana

Protein Variants

Protein Variants Comment Organism
E21Q mutation in putative acid-base catalyst, inactive Arabidopsis thaliana

Inhibitors

Inhibitors Comment Organism Structure
phosphate
-
 Arabidopsis thaliana

Localization

Localization Comment Organism GeneOntology No. Textmining
chloroplast
-
 Arabidopsis thaliana 9507
-

Organism

Organism UniProt Comment Textmining
Arabidopsis thaliana O23346
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information mechanism shows an enzyme-catalyzed formation of a high-energy imidazolate intermediate. Changes in manganese coordination chemistry dominate all aspects of catalysis. In the first part of the reaction, the enzyme harnesses the substrate binding energy to create a distorted, ligand-depleted metal center, which serves to remove kinetic barriers to the production of the imidazolate intermediate. Subsequently, a second switch in coordination chemistry restores the octahedral coordination of the metal ion, leading to critical torsion angle changes to the substrate that are necessary for concomitant production of the diazafulvene Arabidopsis thaliana ?
-
 ?

Synonyms

Synonyms Comment Organism
HisN5B
-
 Arabidopsis thaliana

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
5
-
 phosphate 30°C, pH not specified in the publication Arabidopsis thaliana