Literature summary for 4.2.1.18 extracted from

Kurimoto, K.; Kuwasako, K.; Sandercock, A.; Unzai, S.; Robinson, C.; Muto, Y.; Yokoyama, S.
AU-rich RNA-binding induces changes in the quaternary structure of AUH (2009), Proteins, 75, 360-372.

Search for more literature for 4.2.1.18

Crystallization (Commentary)

Crystallization (Comment)	Organism
AUH is crystallized with a long RNA containing 24 repeats of the AUUU motif. AUH structure is determined as an asymmetric dimer of trimers with a kink in the alignment of the trimer axes, resulting in the formation of two clefts with significantly different sizes	Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da]	Molecular Weight Maximum [Da]	Comment	Organism
89980	-	mass spectroscopy, RNA free AUH	Homo sapiens
221400	-	mass spectroscopy, in the presence of a long RNA containing 24 repeats of the AUUU motif, (AUUU)24A	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q13825	-	-

Subunits

Subunits	Comment	Organism
dimer or trimer	AUH trimer dimerizes upon binding to one molecule of a long RNA containing 24 repeats of the AUUU motif, (AUUU)24A, determined by mass-spectroscopy	Homo sapiens
trimer	mainly exists as a trimer in solution, determined by mass-spectroscopy	Homo sapiens

Synonyms

Synonyms	Comment	Organism
AU RNA binding protein/enoyl-Coenzyme A hydratase	enzyme also possesses an RNA-binding activity to AUUU repeats	Homo sapiens
AUH	-	Homo sapiens

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Release 2023.1 (January 2023)