Inhibitors | Comment | Organism | Structure |
---|---|---|---|
acetoacetyl-CoA | enolate form of acetoacetyl-CoA acts as a competitive inhibitor. 6 molecules of inhibitor are bound per molecule of enzyme | Bos taurus | |
decenoyl-CoA | - |
Bos taurus | |
hexadecenoyl-CoA | - |
Bos taurus | |
hexenoyl-CoA | - |
Bos taurus | |
additional information | no inhibition: ethyl acetoacetate, acetoacetate | Bos taurus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
mitochondrion | - |
Bos taurus | 5739 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Bos taurus | - |
The classification is ambiguous because the stereochemistry of the reaction product is not exactly determined | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Bos taurus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
(2E)-octenoyl-CoA + H2O | 36% of the activity with crotonyl-CoA. The classification is ambiguous because the stereochemistry is not exactly determined | Bos taurus | ? | - |
? | |
crotonyl-CoA + H2O | best substrate. The classification is ambiguous because the stereochemistry is not exactly determined | Bos taurus | ? | - |
? | |
decenoyl-CoA + H2O | 17% of the activity with crotonyl-CoA. The classification is ambiguous because the stereochemistry is not exactly determined | Bos taurus | ? | - |
? | |
dodecenoyl-CoA + H2O | 7% of the activity with crotonyl-CoA. The classification is ambiguous because the stereochemistry is not exactly determined | Bos taurus | ? | - |
? | |
hexadecenoyl-CoA + H2O | 1% of the activity with crotonyl-CoA. The classification is ambiguous because the stereochemistry is not exactly determined | Bos taurus | ? | - |
? | |
hexenoyl-CoA + H2O | 67% of the activity with crotonyl-CoA. The classification is ambiguous because the stereochemistry is not exactly determined | Bos taurus | ? | - |
? | |
tetradecenoyl-CoA + H2O | 2% of the activity with crotonyl-CoA. The classification is ambiguous because the stereochemistry is not exactly determined | Bos taurus | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
hexamer | - |
Bos taurus |
Synonyms | Comment | Organism |
---|---|---|
crotonase | the classification is ambiguous because the stereochemistry is not exactly determined | Bos taurus |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
5667 | - |
crotonyl-CoA | pH 7.5, 25°C | Bos taurus |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.00024 | - |
hexenoyl-CoA | pH 7.5, 25°C | Bos taurus | |
0.00028 | - |
octenoyl-CoA | pH 7.5, 25°C | Bos taurus | |
0.0003 | - |
decenoyl-CoA | pH 7.5, 25°C | Bos taurus | |
0.0004 | - |
dodecenoyl-CoA | pH 7.5, 25°C | Bos taurus | |
0.00042 | - |
tetradecenoyl-CoA | pH 7.5, 25°C | Bos taurus | |
0.0005 | - |
hexadecenoyl-CoA | pH 7.5, 25°C | Bos taurus | |
0.0016 | - |
acetoacetyl-CoA | pH 7.5, 25°C | Bos taurus |